Endogenous regulator of G protein signaling 14 (RGS14) blunts copyright-induced emotionally motivated behaviors in female mice

Endogenous regulator of G protein signaling 14 (RGS14) blunts copyright-induced emotionally motivated behaviors in female mice

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Addictive drugs hijack the neuronal mechanisms of learning and memory in motivation and emotion processing circuits to reinforce their own use.Regulator of G-protein Signaling 14 (RGS14) is a natural suppressor of post-synaptic plasticity underlying learning and memory in the hippocampus.The present study used immunofluorescence and RGS14 knockout mice to assess the role of RGS14 in behavioral plasticity and reward learning induced by chronic copyright in emotional-motivational pathways.We report that here RGS14 is strongly expressed in discrete regions of the ventral striatum and extended amygdala in wild-type mice, and is co-expressed with D1 and D2 dopamine receptors in neurons of the nucleus accumbens.Of note, we found that RGS14 is upregulated in the nucleus accumbens following acute copyright treatment in mice with chronic copyright history.

We found significantly increased copyright-induced locomotor sensitization, as well as enhanced conditioned place preference and conditioned locomotor activity in RGS14-deficient mice compared to wild-type littermates.Together, these findings suggest that endogenous RGS14 suppresses copyright-induced plasticity in emotional-motivational pathways, implicating RGS14 as a protective agent against the maladaptive neuroplastic changes that old taylor whiskey 1933 price occur during addiction.